QUANTUM ANALYSIS OF THE EFFECT OF ERYTHRITOL VS. THE NITROGENATED BASES OF DNA AND RNA CONSTRUCTION
Keywords:
Erithritol, Nitrogenous bases, DNA. RNA, Quantum Chemistry, Hyperchem.Abstract
Erythritol (ETT) ((2R, 3S) -butane-1, 2, 3, 4-tetraol) is a polyalcohol (sugar alcohol) used as a substitute for sweet flavors. The present work shows the theoretical quantum analysis to calculate the effect of ETT on the nitrogenous bases (NB) of the nucleic acids (DNA-RNA). The combination of the compound ETT with the DNA and RNA bases was calculated with the Electron Transfer Coefficient (ETC) theory and design in Hyperchem software. SEPM3 was the specific program used for molecular modeling HOMO-LUMO, BG, EP, and other properties. The water has the highest ETC value of all. For this reason, water can attack the other seven substances in question; but the ETT has a considerable attack power too (it is no good). We calculated ETCs values of the substances in the crossed band, and it can see that the ETT interacts with all NB in oxidative form. It is, in general, concluded that: ETT is an oxidizing agent of both DNA and RNA and due to its average probability the damage it can cause is slow. It is not fulminating.
