KINETICS AND MECHANISTIC STUDY OF ACID CATALYSED HYDROLYSIS OF N-BENZYL-2-FUROHYDROXAMIC ACIDS
Keywords:
Hydroxamic acids; protonation; Bunnett; Bunnett Olsen; Cox Yates.Abstract
The kinetic rate of hydrolysis of some heterocyclic hydroxamic acids N-Benzyl-2-Furohydroxamic Acids BFHA have been investigated in mineral acids in 20 (v/v) dioxane-water medium. Activation parameters have been determined. On the basis of Bunnett, Bunnett-olsen and Cox-Yates excess acidity treatments the mechanism is seen as involving a pre-equilibrium protonation followed by rate determining A-2 type nucleophilic attack by water molecule on the protonated substrate.
